Cdc25mediated
Cdc25-mediated refers to cellular processes driven by the Cdc25 family of dual-specificity phosphatases, which activate cyclin-dependent kinases (Cdks) by removing inhibitory phosphate groups from their activating residue. In most eukaryotes, this action promotes progression from the G2 phase into mitosis by enabling Cdk1 (also called Cdc2 in some species) to trigger mitotic entry in complex with its cyclin partner.
The core mechanism involves dephosphorylation of inhibitory sites on Cdks, typically at a conserved tyrosine (and,
Organismal variation exists in Cdc25 function. In budding yeast, Mih1 is the Cdc25 homolog acting on Cdc28;
Regulation of Cdc25-mediated activation involves multiple layers. DNA damage or replication stress activates checkpoint kinases (such