AOSD
Adult-onset Still's disease (AOSD) is a rare autoinflammatory disorder characterized by systemic inflammation with fevers, arthritis, and a salmon-pink skin rash, along with elevated inflammatory markers. It primarily affects adults, often presenting in the second to fourth decades of life, though onset can occur at any age. The exact cause is unknown, but genetic susceptibility and environmental triggers are thought to contribute, and dysregulated innate immune responses with proinflammatory cytokines play a central role.
Clinical presentation commonly includes quotidian fever spikes (often above 39°C), arthritis that can be symmetrical and
Diagnosis is clinical and by exclusion of infections, malignancies, and other rheumatic diseases. There is no
Treatment ranges from nonsteroidal anti-inflammatory drugs for mild disease to systemic glucocorticoids for more active disease,