4Methylamphetamine

4-Methylamphetamine, also known as 4-MA or para-methylamphetamine, is a stimulant drug of the amphetamine class. It is structurally related to amphetamine, with a methyl group attached to the para position of the phenyl ring. This structural modification can influence its pharmacological properties and effects.

4-MA acts as a central nervous system stimulant. Its mechanism of action primarily involves increasing the release and blocking the reuptake of neurotransmitters such as dopamine, norepinephrine, and serotonin in the brain. This can lead to effects commonly associated with stimulants, including increased alertness, euphoria, energy, and decreased appetite.

The recreational use of 4-MA has been reported, often in contexts where it is sold as a substitute for other amphetamines. However, its use is associated with significant risks. Adverse effects can range from cardiovascular issues like increased heart rate and blood pressure, to psychological effects such as anxiety, paranoia, and insomnia. There have also been reports of more severe adverse events, including hyperthermia and potential neurotoxicity, although comprehensive research on its long-term effects in humans is limited.

In many jurisdictions, 4-MA is a controlled substance due to its stimulant properties and potential for abuse. Its legal status and availability vary internationally. Due to the risks and limited research, its use is generally discouraged.