solubilitybased
Solubilitybased is a term used to describe an approach or methodology in chemistry and related fields that places solubility data at the center of decision making. In a solubilitybased framework, the feasibility and optimization of processes, formulations, and materials are evaluated primarily through the lens of solubility behavior under relevant conditions, including temperature, pH, and solvent composition. The concept is not a single technique but a guiding principle that integrates solubility measurements with design criteria.
Key inputs include solubility curves, saturation concentrations, solubility products, and partition or distribution coefficients. Data are
Applications include pharmaceutical formulation, where solubilitybased design seeks to maximize percent dissolved and bioavailability; environmental engineering,
Typical workflow involves compiling reliable solubility data, selecting candidate solvents or excipients based on predicted solubility,
Limitations include potential neglect of kinetics, solid-state transformations, and complex multicomponent interactions. Solubilitybased methods are most