rs429358
rs429358 is a single nucleotide polymorphism in the apolipoprotein E (APOE) gene on chromosome 19. It involves a cytosine to thymine substitution that changes the codon for amino acid 112 from cysteine to arginine. Specifically, the C allele encodes cysteine at position 112, while the T allele encodes arginine.
This SNP does not act alone. Together with rs7412, another APOE variant, rs429358 helps define the three
Clinically, the APOE ε4 allele is associated with an increased lifetime risk of late-onset Alzheimer's disease
rs429358 has been extensively studied in genetic research and is frequently included in studies of APOE