rs7412

rs7412 is a single nucleotide polymorphism (SNP) located in the APOA1 gene on chromosome 11. APOA1 is a gene that encodes apolipoprotein A-I, a major component of high-density lipoprotein (HDL) cholesterol. HDL cholesterol is often referred to as "good" cholesterol because it helps remove cholesterol from the arteries.

The rs7412 SNP is a common variant, meaning it occurs frequently in the human population. It is characterized by a change from cytosine (C) to thymine (T) at a specific position. Individuals can have one of three genotypes for this SNP: CC, CT, or TT.

Research has investigated the association of rs7412 with various health conditions, particularly cardiovascular disease and lipid levels. Some studies suggest that certain genotypes of rs7412 may be linked to differences in HDL cholesterol levels and an increased or decreased risk of cardiovascular events. However, findings across studies are not always consistent, and the precise clinical significance of this SNP is still an area of ongoing research. Its role in metabolic pathways and its interaction with other genetic and environmental factors are subjects of continued investigation.