periurethral

Periurethral describes the region surrounding the urethra. The term is used in anatomy and clinical medicine to denote tissues, glands, ducts, and spaces located adjacent to the urethral lumen in both sexes.

In males, the penile urethra is enveloped by periurethral connective tissue and contains mucous-producing glands along its length, known as the glands of Littre. These periurethral glands contribute to lubrication and can be involved in inflammatory processes. In females, the periurethral region includes the paraurethral glands (Skene's glands) near the urethral opening, as well as surrounding connective tissue and vascular structures.

Clinical significance often centers on periurethral pathology, such as infections of the periurethral glands or surrounding tissues, which can lead to periurethral abscess or cellulitis. Symptoms typically include localized pain, swelling, dysuria, and sometimes purulent discharge. Risk factors include urethral instrumentation, trauma, and sexually transmitted infections. Diagnosis is usually clinical, with imaging such as ultrasound or MRI employed if a mass or complex infection is suspected. Management generally involves appropriate antimicrobial therapy and, when indicated, drainage of abscesses.

Periurethral conditions can also include rare fistulous tracts or inflammatory processes extending from the periurethral space. In clinical practice, the term aids in localizing disease and guiding examination, imaging, and treatment decisions around the urethral region.