p19ARF
p19ARF is the protein product of the Arf gene in mice, produced by an alternative reading frame of the Cdkn2a locus. In humans, the orthologous product is p14ARF, encoded by the same genomic region via a different reading frame. Both p19ARF and p14ARF are small tumor suppressors that become activated in response to oncogenic stress and help preserve genomic integrity.
The primary function of ARF proteins is to regulate the p53 tumor suppressor pathway. ARF binds to
Expression of ARF is typically low in most normal tissues but is upregulated by oncogenic signals such
Research use highlights the role of p19ARF/p14ARF in regulating the p53 pathway and in mediating responses