liganddesign
Ligand design is the intentional creation and refinement of molecules that bind to a central atom or biomolecule to achieve a desired chemical, catalytic, or biological outcome. The concept spans coordination chemistry, organometallic catalysis, materials science, and medicinal chemistry, where ligands are tailored to control binding strength, geometry, and reactivity while minimizing unwanted interactions.
In coordination chemistry and catalysis, ligands are designed to tune metal centers. Key considerations include denticity
In medicinal chemistry and biochemistry, ligands act as drugs, probes, or imaging agents that engage receptors,
Applications span asymmetric catalysis, metal-based therapeutics, MRI contrast agents, and sensory materials. Challenges include achieving high