lhypouricémie

L'hypouricémie, also known as low uric acid levels, refers to a condition where the concentration of uric acid in the blood is below the normal range. Uric acid is a waste product produced when the body breaks down purines, which are found in certain foods and are also produced naturally by the body. Typically, uric acid is filtered by the kidneys and excreted in urine.

Several factors can contribute to hypouricémie. These include genetic conditions that affect kidney function, leading to increased excretion of uric acid, or conditions that reduce uric acid production. Certain medications, such as probenecid or allopurinol (though allopurinol is more commonly used to treat hyperuricemia), can also lower uric acid levels. Nutritional deficiencies, particularly those affecting purine metabolism, and some autoimmune diseases have also been linked to hypouricémie.

In many cases, hypouricémie is asymptomatic and discovered incidentally during routine blood tests. However, in some individuals, particularly those with genetic conditions like renal hypouricemia, it can be associated with an increased risk of kidney stones, specifically uric acid stones, and in rare instances, acute kidney injury, especially after strenuous exercise. The management of hypouricémie depends on its underlying cause and whether it is associated with any symptoms or complications. If it is an incidental finding without symptoms, no specific treatment may be required. If complications arise, addressing the underlying cause and managing symptoms is important.