laminin2
Laminin-2 is a member of the laminin family of extracellular matrix proteins. In humans, laminin-2 refers to the heterotrimer consisting of the alpha-2, beta-1, and gamma-1 chains, commonly called laminin-211. It is a major component of basement membranes in skeletal muscle and peripheral nerves and contributes to tissue architecture, cell adhesion, and signaling.
Laminin-2 interacts with cell surface receptors such as dystroglycan and integrins, and with other basement membrane
In humans, mutations in LAMA2 cause merosin-deficient congenital muscular dystrophy (MDC1A) and related LAMA2-related muscular dystrophy.
Laminin-2 is also studied in animal models to understand muscle and nerve development, and its expression is