eksportinmediated
Exportin-mediated transport refers to the process by which exportins, a family of nuclear transport receptors, mediate the export of selected proteins and RNAs from the nucleus to the cytoplasm through the nuclear pore complex. Cargo molecules typically contain nuclear export signals (NES) that are recognized by exportins in the presence of RanGTP.
Mechanism: In the nucleoplasm, exportins bind NES-containing cargo in a complex with RanGTP. The complex translocates
Examples and relevance: The best characterized exportin is exportin-1 (XPO1, also known as CRM1). It exports
Clinical and biological significance: Proper exportin function is essential for cell cycle control, gene expression, and