deferoxamin
Deferoxamine, also known as desferrioxamine, is an iron chelating agent used to treat iron overload and acute iron poisoning. It binds ferric iron (Fe3+) with high affinity, forming ferrioxamine complexes that are water soluble and primarily excreted by the kidneys.
Mechanism of action is based on chelation: deferoxamine acts as a hexadentate chelator, sequestering iron that
Medical uses include treatment of acute iron poisoning, especially in children, and management of chronic iron
Administration and dosing are determined by clinical indication and patient factors. Deferoxamine is given by intravenous
Adverse effects can include infusion-site reactions, fever, rash, and hypotension with rapid infusion. Long-term use has
Deferoxamine remains one of the primary agents for iron chelation and is distinguished from other chelators