centrosomederived

Centrosomederived is an adjective used in cell biology to describe structures, molecules, or signals that originate from or are organized by the centrosome, the primary microtubule organizing center in many animal cells. The centrosome typically comprises a pair of centrioles surrounded by pericentriolar material that nucleates and anchors microtubules during interphase and mitosis.

Key components associated with centrosomederived microtubule nucleation include the γ-tubulin ring complex (γ-TuRC) and various centrosomal scaffold proteins such as CEP192, CEP152, CDK5RAP2, and pericentrin, which anchor γ-TuRC to the pericentriolar material. Through these factors, the centrosome organizes a radial array of microtubules that forms the spindle poles during mitosis and fosters cell polarity in interphase. In some cells, centrioles serve as basal bodies that convert centrosomal activity into cilia or flagella formation, linking centrosomederived processes to ciliogenesis.

Centrosomederived microtubule nucleation contributes to spindle assembly, orientation, and genome stability. It can be complemented by non-centrosomal microtubule organizing centers in differentiated cells, showing that centrosome-derived activity is part of a broader cytoskeletal network rather than an isolated process.

Abnormal centrosome number or structure—centrosome amplification, fragmentation, or dysfunction—has been associated with cancer, microcephaly, and ciliopathies. Research into centrosomederived pathways informs understanding of cell division, polarity, and disease, and highlights interactions with signaling pathways that regulate cell cycle progression.