baselineserumurinezuur

Baselineserumurinezuur is a term used to describe the baseline concentration of uric acid in blood serum, typically measured at the start of a clinical assessment or before beginning an intervention. It is not a distinct chemical compound, but rather a reference value that provides context for subsequent measurements and treatment decisions.

Uric acid is the end product of purine metabolism and is normally filtered by the kidneys. Baseline serum uric acid levels help assess a patient’s risk for conditions such as gout, kidney stones, and chronic kidney disease, and they guide decisions about treatment strategies, including urate-lowering therapy or adjustments to diuretics and other medications.

Measurement of baseline serum uric acid is usually performed using enzymatic assays (such as the uricase method) or by high-performance liquid chromatography. Results are reported in mg/dL or µmol/L, with reference ranges varying by laboratory and population. Typical reference values approximate 3.4–7.0 mg/dL for men and 2.4–6.0 mg/dL for women, but exact ranges depend on the assay and lab.

Interpretation of baseline values requires clinical context, including age, sex, renal function, medications, and dietary factors. Baseline values are often used to stratify participants in clinical trials, to monitor response to treatment, and to establish goals for uric acid reduction. Because a single measurement can be influenced by recent meals, hydration, or acute illness, clinicians may obtain repeat measurements to confirm the baseline value.

Limitations include biological variability and measurement error; baseline data are most informative when integrated with longitudinal measurements and patient history.