acetylLkarnitiini

AcetylLkarnitiini, more commonly known as acetyl-L-carnitine (ALCAR), is the acetylated form of L-carnitine, a quaternary ammonium compound involved in fatty acid transport into mitochondria and energy production. In contrast to L-carnitine, acetyl-L-carnitine can cross the blood-brain barrier more readily, enabling central nervous system effects. In some languages or contexts, the compound is rendered as acetylLkarnitiini.

Biochemical role and pharmacology: ALCAR donates acetyl groups, forming acetyl-CoA, which feeds into the citric acid cycle and, in the brain, supports acetylcholine synthesis. It may influence mitochondrial function, neurotrophic signaling, and antioxidant defenses. Endogenous production occurs in multiple tissues, with dietary sources providing additional amounts. The compound is typically taken as a dietary supplement rather than a prescription drug.

Uses and evidence: ALCAR is marketed for aging-related cognitive decline, mood disorders, peripheral neuropathy, and fatigue. Clinical trials have reported modest cognitive or mood benefits in some elderly populations, but findings are inconsistent and results are not conclusive. It is not approved as a prescription treatment for these indications in most jurisdictions. Typical supplemental doses range from 500 to 2,000 mg per day, often divided.

Safety and regulation: ALCAR is generally well tolerated. Reported side effects include gastrointestinal symptoms and, less commonly, restlessness or insomnia. Long-term safety at standard supplement doses appears acceptable, though evidence quality varies by condition. As with any supplement, users should consider interactions with medications and consult healthcare professionals when in doubt.