Vevssamspill

Vevssamspill is a term used in biology to describe the coordinated communication between different tissue components, including parenchymal cells, stromal cells, and the extracellular matrix (ECM). The concept emphasizes that tissue function emerges from interactions across cellular and extracellular elements rather than from isolated cell types. It covers both biochemical signaling and biophysical cues.

Mechanisms include paracrine and autocrine signaling, ligand-receptor interactions, and the release of extracellular vesicles that shuttle proteins, lipids, and nucleic acids. Biophysical aspects such as matrix stiffness, fiber orientation, and mechanical forces influence cell behavior through mechanotransduction pathways, often mediated by integrins and the cytoskeleton. ECM remodeling by cells also alters signaling landscapes, enabling feedback between tissue compartments.

Vevssamspill operates throughout development, tissue maintenance, and repair. In organogenesis, coordinated signaling between epithelial and mesenchymal tissues guides patterning. In wounds, interactions among immune cells, fibroblasts, and ECM drive healing and scarring. In disease, dysregulated vevssamspill can contribute to fibrosis, cancer invasion, and chronic inflammation.

Researchers study vevssamspill using co-culture systems, organoids, imaging of signaling gradients, and computational models that integrate cellular and matrix factors. Understanding the tissue-wide network of interactions informs regenerative medicine, tissue engineering, and therapeutic strategies targeting the tissue microenvironment.