Standardimine

Standardimine is a synthetic organic compound used as a universal calibration standard in analytical chemistry. It is designed to be an imine-based reference molecule that provides reproducible spectral and chromatographic responses across instruments.

The compound is typically a solid at room temperature, with good stability to air and light, and solubility in common organic solvents. Its core imine functionality is paired with a rigid aromatic framework to minimize conformational changes under routine analytical conditions.

Standardimine is produced by a condensation reaction between selected aldehydes and amines, followed by purification to high chemical purity. It is distributed in certified batches by standardization organizations and suppliers to ensure traceability.

It serves as a calibration standard for 1H and 13C NMR, infrared spectroscopy, UV-visible spectroscopy, and chromatographic methods such as HPLC and GC-MS. Laboratories use it to normalize instrument response, validate methods, and compare results across platforms.

As with other synthetic chemicals, standardimine should be handled with standard laboratory precautions, including gloves and eye protection. There are no widely reported acute hazards at typical calibration concentrations, but local regulations apply.

Since its introduction, standardimine has been referenced in analytical chemistry guidelines and is occasionally discussed as a best-practice reference material in inter-laboratory studies.