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SAP30

SAP30, or Sin3-associated protein 30 kDa, is a protein encoded by the SAP30 gene in humans. It is a component of the Sin3 transcriptional corepressor complexes, which play a central role in regulating gene expression through chromatin modification. SAP30 is part of the Sin3A- and Sin3B-containing complexes that recruit histone deacetylases to promoters, promoting histone deacetylation, chromatin condensation, and transcriptional repression.

In the Sin3 corepressor assemblies, SAP30 interacts with other subunits such as Sin3 proteins and SAP18, and

SAP30 is generally localized to the nucleus and shows broad expression across tissues in humans and other

Clinical relevance for SAP30 is not tied to a single disease gene but rather to the broader

it
has
homologs
in
other
species
as
part
of
the
conserved
Sin3/HDAC
regulatory
module.
A
related
protein,
SAP30L
(SAP30-like),
shares
sequence
similarity
and
can
participate
in
similar
complex
formations,
contributing
to
the
versatility
of
Sin3-dependent
repression.
vertebrates.
Through
its
role
in
recruiting
histone
deacetylases
and
assembling
repressive
chromatin,
SAP30
influences
the
expression
of
various
target
genes
and
participates
in
diverse
cellular
processes,
including
development,
cell
cycle
regulation,
and
responses
to
cellular
stress
in
model
systems.
function
of
Sin3/HDAC-mediated
transcriptional
control.
Disruptions
to
this
regulatory
axis
can
affect
gene
expression
programs
and
cellular
behavior,
making
SAP30
a
subject
of
ongoing
research
in
understanding
chromatin-based
transcriptional
regulation
and
its
impact
on
health
and
disease.