RAGEactiviteit
RAGEactiviteit refers to the activity of the receptor for advanced glycation end products (RAGE), a pattern recognition receptor that responds to diverse ligands and modulates inflammatory and oxidative stress signaling.
RAGE belongs to the immunoglobulin superfamily; upon ligand binding, it activates intracellular signaling pathways such as
RAGE ligands include advanced glycation end products (AGEs), HMGB1, members of the S100 protein family (notably
Clinically, increased RAGE activity is linked to chronic inflammatory and degenerative conditions, including diabetic complications (nephropathy,
Therapeutically, strategies aim to reduce RAGE activation or block ligand binding; approaches include decoy receptors (sRAGE),
Research status: RAGEactiviteit remains an active area of investigation, with ongoing studies to clarify causal roles