QTsyndrom
QT syndrome, also known as long QT syndrome (LQTS), is a cardiac channelopathy and repolarization disorder characterized by a prolonged QT interval on the surface electrocardiogram. Prolongation increases the risk of torsades de pointes, a rapid, chaotic form of ventricular tachycardia that can lead to syncope or sudden cardiac death. QT syndrome can be congenital or acquired.
Congenital LQTS results from mutations in genes encoding cardiac ion channels, most notably KCNQ1 (LQT1), KCNH2
Acquired prolongation can be caused by medications that block potassium channels or by electrolyte disturbances, hypothyroidism,
Diagnosis relies on an ECG showing a prolonged QT interval, corrected for heart rate (QTc). Clinical tools
Prognosis depends on subtype and risk factors. With appropriate treatment and lifestyle measures, life expectancy improves,