Plasmalogenlevel
Plasmalogenlevel refers to the amount or proportion of plasmalogens present in a biological sample. Plasmalogens are a class of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position, with common head groups being phosphatidylethanolamine (PE plasmalogens) and phosphatidylcholine (PC plasmalogens). The plasmalogen level can be expressed as a molar fraction of total glycerophospholipids or as an absolute concentration in a sample such as blood plasma, erythrocytes, fibroblasts, or tissue.
Plasmalogens are synthesized in peroxisomes and, to a lesser extent, the endoplasmic reticulum. They are thought
Measurement of plasmalogen levels is performed mainly by lipidomics methods, typically mass spectrometry-based assays such as
Clinical relevance: plasmalogen levels are reduced in several peroxisomal disorders, including Zellweiger spectrum disorders and rhizomelic