Oxicam
Oxicam is a subclass of nonsteroidal anti-inflammatory drugs (NSAIDs) that share a common chemical structure and are used to treat pain and inflammation. The class includes drugs such as piroxicam, meloxicam, tenoxicam, lornoxicam, and sudoxicam. Oxicams inhibit the activity of cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins that mediate inflammation, pain, and fever. They differ in their degree of COX-1 versus COX-2 inhibition; for example, meloxicam is relatively COX-2 selective at typical therapeutic doses, while piroxicam is generally non-selective.
Clinical use: Oxicams are used for symptomatic relief in rheumatic diseases such as osteoarthritis and rheumatoid
Pharmacokinetics: Most oxicam NSAIDs are taken orally and have good bioavailability. They are largely protein-bound, undergo
Adverse effects and safety: Common NSAID-associated adverse effects include gastrointestinal irritation, dyspepsia, gastritis, and risk of
History: The oxicam class has been in medical use since the late 20th century, and its members