NPY2

NPY2, also known as the Neuropeptide Y receptor Y2, is a protein encoded by the NPY2 gene in humans. This gene is a member of the G protein-coupled receptor superfamily. NPY2 is primarily expressed in the brain, particularly in areas associated with appetite regulation, mood, and stress response. It is a crucial component of the neuropeptide Y signaling system.

Neuropeptide Y (NPY) is a peptide neurotransmitter that plays a significant role in various physiological processes, including feeding behavior, anxiety, and cardiovascular regulation. NPY exerts its effects by binding to several receptor subtypes, with NPY2 being one of the high-affinity receptors. Activation of NPY2 by NPY leads to a cascade of intracellular events, typically mediated by inhibitory G proteins, which can modulate neuronal activity.

Research suggests that NPY2 receptors are involved in promoting food intake, particularly in response to stress or fasting. They have also been implicated in anxiety-like behaviors and stress resilience. Furthermore, NPY2 signaling has been linked to cardiovascular functions, including blood pressure regulation. Dysregulation of NPY2 has been associated with conditions such as obesity, depression, and cardiovascular diseases, making it a potential therapeutic target for these disorders.