Mycelex

Mycelex is a brand-name antifungal medication whose active ingredient is clotrimazole. It is used to treat fungal infections caused by Candida species, most notably oral candidiasis (thrush). The form most commonly associated with the name is the troche, a small lozenge meant to dissolve slowly in the mouth to release clotrimazole. In some markets, clotrimazole products may bear different brand names for other routes of administration, but Mycelex is primarily linked to the oral troche formulation.

Mechanism of action: clotrimazole belongs to the azole class of antifungals. It inhibits the fungal enzyme 14α-demethylase, a key step in ergosterol synthesis, disrupting the integrity of the fungal cell membrane and inhibiting growth. It is generally fungistatic, with fungicidal activity at higher concentrations for certain organisms.

Forms, dosing, and administration: Mycelex Troches are typically 10 mg each and are taken by slowly dissolving one troche in the mouth several times daily. A commonly cited regimen is five times daily for about 14 days, but actual dosing varies by country and clinical guidance. The lozenge should not be chewed or swallowed whole; avoid eating or drinking immediately after administration to maximize local effect. Always follow a healthcare provider’s instructions and the product package insert.

Side effects and safety: adverse effects are usually mild and localized, including mouth irritation, unusual taste, or nausea. Rare systemic adverse events can occur. Contraindications include known allergy to clotrimazole or other azoles. Use in pregnancy or breastfeeding should be guided by a clinician. Inform a provider of concurrent medications, as azole antifungals can interact with other drugs, though systemic exposure from troches is limited.

History and availability: Mycelex has been used for decades in various countries, with generic clotrimazole products widely available. Availability and brand labeling vary by region.