Membranin
Membranin is a conserved membrane-associated protein found in eukaryotic species, encoded by the MBRN gene. It is implicated in the maintenance of plasma membrane integrity and in the regulation of vesicle trafficking.
The protein was first identified in a proteomic survey of endomembrane compartments and was named for its
Membranin is a small protein, roughly 140 to 170 amino acids in length, and is predicted to
Localization is predominantly to endoplasmic reticulum and Golgi membranes, with weaker presence at the plasma membrane
Functionally, genetic and biochemical data point to a role in vesicle budding and membrane curvature regulation.
Mechanistically, phosphorylation of serine residues within cytosolic regions can modulate interaction with partner proteins, and interactions
Membranin is of interest for understanding membrane trafficking and dynamics, with potential applications in synthetic biology