Lyrica

Lyrica is the brand name for pregabalin, a prescription medication developed by Pfizer. It is an anticonvulsant and analgesic that does not act directly on GABA receptors. Instead, pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several excitatory neurotransmitters and dampening neuronal excitability.

Approved indications include neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia, fibromyalgia, and as an adjunctive therapy for adults with partial-onset seizures. Availability and approved uses vary by country; in the United States, these are the primary indications. Lyrica is typically prescribed in oral form and taken in divided doses, with dosing tailored to the specific condition and patient, often requiring gradual titration. It is cleared from the body primarily by renal excretion of unchanged drug, and the half-life is about 6 hours in individuals with normal kidney function. Dose adjustments are common for renal impairment. It is classified as a Schedule V controlled substance in the United States due to potential for abuse and dependence.

Common side effects include dizziness, somnolence, dry mouth, edema, weight gain, blurred vision, and concentration difficulties. Serous adverse effects are uncommon but can include mood changes, confusion, angioedema, hypersensitivity reactions, and suicidality; patients should be monitored for changes in mood or behavior, especially during initiation or dose changes. Abrupt discontinuation can lead to withdrawal-like symptoms, so gradual tapering is advised under medical supervision.

Pregnancy and lactation: in the United States, pregabalin is a pregnancy category C drug; it should be used during pregnancy only if the potential benefits justify potential risks. It is excreted in breast milk, so nursing considerations are recommended. Interactions: concurrent use with other central nervous system depressants or alcohol can increase sedation and dizziness, and dose adjustments may be needed with other medications.