JWH133

JWH133 is a synthetic cannabinoid, meaning it is a man-made chemical that interacts with the cannabinoid receptors in the body. It was developed by John W. Huffman at Clemson University in the 1990s as part of research into the effects of cannabis. JWH133 is known for its high affinity for the CB1 receptor, which is largely responsible for the psychoactive effects of THC, the main psychoactive compound in cannabis.

While initially synthesized for research purposes, JWH133 gained notoriety as a component in some "spice" or "k2" products, which are often marketed as herbal incense. These products are not intended for human consumption and can contain a variety of synthetic cannabinoids, including JWH133, which have been found to produce unpredictable and potentially dangerous side effects. The use of JWH133 and similar synthetic cannabinoids has been linked to adverse health outcomes, including anxiety, paranoia, hallucinations, seizures, and cardiovascular problems. Due to these risks and the potential for abuse, JWH133 has been made a controlled substance in many countries.