JAG1Notch
Jagged1 (JAG1) is a transmembrane ligand of the Notch family of signaling receptors and is encoded by the JAG1 gene located on chromosome 20q12. JAG1 binds to Notch receptors on adjacent cells, triggering proteolytic cleavage and release of the Notch intracellular domain, which translocates to the nucleus to regulate transcription of target genes involved in cell fate, proliferation, differentiation and apoptosis.
During embryogenesis, JAG1–Notch signaling is essential for the development of the heart, kidneys, lungs, and blood
JAG1 expression is tightly controlled at transcriptional, post‑transcriptional and post‑translational levels. MicroRNAs, such as miR‑125b, can
Mutations in JAG1 underlie Alagille syndrome, a multisystem disorder characterized by bile duct paucity, cardiac malformations,
Researchers study JAG1–Notch interactions to elucidate developmental biology, repair mechanisms and potential therapeutic targets for congenital