G6PDaktivitás

G6PDaktivitás refers to the activity level of the enzyme glucose-6-phosphate dehydrogenase (G6PD). This enzyme is crucial for the normal functioning of red blood cells. It plays a vital role in the pentose phosphate pathway, a metabolic process that generates NADPH. NADPH is essential for protecting red blood cells from oxidative stress, which can be caused by various factors including certain medications, fava beans, and infections.

Reduced G6PD activity can lead to a condition known as G6PD deficiency, an inherited disorder that is more common in certain ethnic groups, particularly those of Mediterranean, African, and Asian descent. In individuals with G6PD deficiency, red blood cells are more vulnerable to damage when exposed to oxidative stressors. This damage can result in hemolysis, the premature destruction of red blood cells, leading to hemolytic anemia. Symptoms of hemolytic anemia can include jaundice, fatigue, dark urine, and shortness of breath.

Testing for G6PDaktivitás is often performed when G6PD deficiency is suspected, especially in newborns who may exhibit signs of jaundice, or in individuals who have experienced an episode of hemolytic anemia after exposure to a potential trigger. Diagnosis typically involves a blood test to measure the enzyme's activity level. Management of G6PD deficiency primarily involves avoiding known oxidative triggers to prevent hemolytic episodes.