Flunixin

Flunixin is a non-steroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine. It belongs to the class of fenamate NSAIDs and is primarily known for its analgesic, anti-inflammatory, and antipyretic properties. Flunixin works by inhibiting cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. Prostaglandins are key mediators of inflammation, pain, and fever. By reducing prostaglandin synthesis, flunixin effectively alleviates these symptoms.

In veterinary practice, flunixin is frequently administered to horses, cattle, and swine. In horses, it is often used to manage pain associated with colic, laminitis, and musculoskeletal disorders. In cattle, it is employed to reduce fever and inflammation in conditions such as respiratory disease and endotoxemia. Swine may receive flunixin for the treatment of respiratory disease and mastitis-metritis-agalactia (MMA) syndrome.

Flunixin is typically available in injectable and oral formulations. The route of administration and dosage depend on the species, the condition being treated, and the weight of the animal. Common side effects associated with NSAID use, including flunixin, can include gastrointestinal upset, kidney problems, and gastric ulceration, especially with prolonged use or at high doses. Therefore, it is crucial that flunixin is administered under the guidance of a qualified veterinarian who can determine the appropriate use and monitor for potential adverse effects. Withdrawal times must be observed to ensure that meat and milk from treated animals are safe for consumption.