Expiarray

Expiarray refers to a family of protein expression systems developed by Thermo Fisher Scientific. These systems are designed for the rapid and efficient production of recombinant proteins, particularly antibodies and other complex glycoproteins. The core of the Expiarray system is a proprietary mammalian cell line, typically Chinese Hamster Ovary (CHO) cells, engineered for high-density suspension culture and enhanced protein secretion.

The Expiarray platform offers several advantages for protein production. Its high-density culture capabilities allow for significantly increased cell densities compared to traditional methods, leading to higher protein titers in a shorter timeframe. The optimized cell line and culture media are designed to support robust cell growth and high-level expression of correctly folded and post-translationally modified proteins. This is especially important for therapeutic proteins that require specific glycosylation patterns for their biological activity and stability.

Key components of the Expiarray system include specialized transfection reagents and optimized culture media formulations. These components work synergistically to maximize protein yield and quality. The system is often employed in research settings for antibody discovery and development, as well as in the preclinical production of biopharmaceuticals. Its design aims to streamline the workflow from gene cloning to protein purification, making it a valuable tool for scientists working on protein-based therapeutics and diagnostics.