Endometriumrisico

Endometriumrisico is a term used to describe the overall risk profile for diseases of the endometrium, the inner lining of the uterus. It is not a formal medical diagnosis, but a concept that clinicians and researchers may use to summarize factors that influence the risk of endometrial cancer and other endometrial conditions.

Risk factors for endometriumrisico include both non-modifiable and modifiable elements. Non-modifiable factors encompass age, with most endometrial cancers occurring in postmenopausal women, and genetic predispositions such as Lynch syndrome, as well as a family history of related cancers. Previous pelvic radiation can also play a role.

Modifiable factors that influence endometriumrisico involve body weight and metabolic health, such as obesity, diabetes, and hypertension. Reproductive history that increases lifetime estrogen exposure—early menarche, late menopause, nulliparity or first pregnancy late in life—also elevates risk. Unopposed estrogen therapy and, in some contexts, the use of tamoxifen can raise endometrial cancer risk. Lifestyle factors such as physical inactivity contribute as well.

Precursor conditions and screening: endometrial hyperplasia, particularly with atypia, is a recognized step that can precede cancer. In clinical practice, evaluation is typically prompted by symptoms like abnormal uterine bleeding. Diagnostic tools include transvaginal ultrasound to assess endometrial thickness, endometrial biopsy, and hysteroscopy when indicated. Genetic counseling may be considered for individuals with a strong family history or suspected Lynch syndrome.

Prevention and management focus on modifiable factors, weight management, control of metabolic conditions, appropriate use of hormonal therapies, and timely treatment of hyperplasia, all aimed at reducing endometriumrisico.