CTBP
CtBP, or C-terminal binding protein, refers to a family of transcriptional corepressors in animals, represented in humans by two paralogs: CTBP1 and CTBP2. CtBP proteins function as chromatin-associated corepressors that help repress target genes in cooperation with sequence-specific transcription factors. They are conserved from flies to humans and play roles in development, cellular differentiation, and metabolism, as well as in cancer progression through regulation of epithelial-mem
brain EMT processes and gene expression programs.
CtBP proteins are dimeric, NAD+-binding enzymes with a catalytic-like N-terminal domain and a C-terminal dimerization region.
Biological roles of CtBP include regulation of development and cell fate decisions, control of genes involved
CtBP2 and CtBP1 differ in isoform expression and subcellular localization, with multiple splice variants giving rise