CTBP2

CTBP2, also known as C-terminal binding protein 2, is a protein that plays a crucial role in various cellular processes, including gene regulation, apoptosis, and cell proliferation. It is a member of the CTBP family, which are transcriptional corepressors that interact with a variety of transcription factors. CTBP2 is characterized by its N-terminal pyridine nucleotide binding domain and its C-terminal protein-protein interaction domain. This dual functionality allows it to bridge the gap between transcription factors and other regulatory proteins, thereby modulating gene expression.

The expression of CTBP2 is found in a wide range of tissues and is particularly important during embryonic development. It has been implicated in the development of the nervous system and in the regulation of cell fate decisions. Dysregulation of CTBP2 has been associated with several diseases, including cancer, where it can act as either an oncogene or a tumor suppressor depending on the cellular context and specific signaling pathways involved. Its interaction with proteins like p53 and Rb highlights its involvement in the control of cell cycle progression and DNA repair. Research into CTBP2 continues to uncover its complex roles in maintaining cellular homeostasis and its potential as a therapeutic target.