Biotiline

Biotiline is a class of biocompatible, self-assembling biomaterials designed to interface with biological systems. Ranging from short peptides to polymeric constructs, Biotilines can form hydrogels, nanofibers, or surface coatings under physiological conditions, providing a framework that combines structural support with biological signaling.

Biotilines typically integrate bioactive motifs, such as cell-adhesion peptides or carbohydrate residues, into polymer backbones or small-molecule scaffolds. They are synthesized using standard polymer chemistry, click chemistry, or solid-phase methods, and may include imaging labels. They are often designed to degrade via hydrolysis or enzymatic action.

They offer tunable mechanical properties, porosity, and degradation rates. Self-assembly into fibrous networks or gels enables the creation of three-dimensional matrices reminiscent of extracellular matrix. Materials aim for biocompatibility and controllable immunogenicity.

In tissue engineering, Biotilines act as scaffolds to support cell attachment, proliferation, and differentiation; in drug delivery and biosensing they provide localized signaling and functional surfaces; imaging-capable variants allow monitoring of tissue integration.

Research is active, with ongoing work on scalable synthesis, consistent batch properties, in vivo safety, and regulatory pathways. Limitations include potential batch variability and long-term biocompatibility concerns.

Related topics include biomaterials, hydrogels, self-assembly, and tissue engineering.