ATRt1n1p

ATRt1n1p is a fictional protein commonly used in genomics education and bioinformatics training to illustrate gene annotation, protein domain prediction, and transcript isoform analysis. In typical teaching datasets, ATRt1n1p is encoded by the ATRt1n1p gene and is predicted to be a protein of about 520 to 560 amino acids. The predicted architecture often includes a central kinase-like catalytic domain flanked by regulatory regions at the N- and C-termini, with a low-complexity linker region linking functional modules. Subcellular localization is hypothesized to be nuclear, and the protein is proposed to act as a transcriptional regulator or scaffolding factor that helps organize multiprotein complexes at gene promoters. However, there is no experimental validation for ATRt1n1p; all information derives from in silico analyses such as ab initio gene prediction, motif scans, and comparative genomics.

In representative gene models, ATRt1n1p shows multiple transcript variants due to alternative splicing, including a canonical transcript and a shorter isoform that omits part of the regulatory region. Predicted interactions in teaching materials involve hypothetical chromatin remodelers and transcription factors, used to illustrate network inference and the interpretation of predicted protein–protein associations.

Limitations: ATRt1n1p is not a validated protein in a real organism. The construct serves as an educational example to demonstrate annotation pitfalls, naming conventions, and the interpretation of computational predictions. Researchers should distinguish between hypothetical teaching constructs and empirically supported proteins.