99mTcECD
99mTc-ECD, also known as technetium-99m ethyl cysteinate dimer or ceretec, is a radiopharmaceutical used for brain perfusion SPECT imaging. It consists of the radioisotope technetium-99m bound to an ethyl cysteinate dimer ligand. After intravenous injection, its lipophilicity allows it to cross the blood–brain barrier and enter brain tissue, where it is rapidly converted to a hydrophilic, trapped form, yielding a static distribution that reflects cerebral blood flow at the time of injection.
Imaging is typically performed about 30 to 60 minutes after injection, with optional delayed imaging possible.
Clinical indications include assessment of cerebral perfusion in acute ischemic stroke and transient ischemic attack, characterization
Safety considerations are similar to other Tc-99m radiopharmaceuticals: transient adverse effects are uncommon; hypersensitivity is possible;