transcriptionassociated

Transcriptionassociated is a descriptor used in molecular biology and genomics to refer to elements, processes, or features that are linked to transcription, the synthesis of RNA from a DNA template typically carried out by RNA polymerase II in eukaryotes. It is not a formal, standalone category but a contextual label applied across studies to indicate functional connections to transcription.

In molecular biology, transcription-associated proteins are cofactors that interact with the transcription machinery to regulate initiation, elongation, pausing, or termination. This category includes transcription factors, coactivators, elongation factors, and components of the mediator complex, all of which influence how transcription proceeds and is coordinated with other cellular processes.

Transcription-associated chromatin modifications and remodelers shape the accessibility of DNA and the efficiency of transcription. Epigenetic marks commonly described in this context include histone modifications such as H3K4me3 at promoters and H3K27ac at active enhancers, which reflect transcription-related regulatory activity and chromatin state.

The term also appears in reference to RNA processing events that accompany transcription, including 5' capping, splicing, and 3' end formation, as well as transcription-coupled DNA repair pathways that target lesions on the transcribed strand. These processes are closely tied to transcription and influence RNA maturity and genome integrity.

In genomics and transcriptomics, researchers may label genomic regions, transcripts, or epigenetic states as transcriptionassociated when their activity or occurrence correlates with transcription levels, promoter activity, or RNA synthesis. The usage emphasizes a functional linkage to transcription rather than implying a discrete molecular class.