sárþreyta

Sárþreyta, often translated as wound fatigue or wound tiredness, is a phenomenon observed in chronic wounds. It describes a state where the wound's healing process stalls or significantly slows down despite appropriate wound care. This lack of progress is not necessarily due to infection or inadequate treatment but rather a localized cellular and molecular exhaustion within the wound environment.

The underlying mechanisms of sárþreyta are complex and still being investigated. It is believed to involve the prolonged presence of inflammatory mediators, excessive matrix metalloproteinases (MMPs) that degrade the extracellular matrix, and impaired cellular functions of key players in wound healing such as fibroblasts and keratinocytes. These cells may become senescent or unresponsive to growth factors, leading to a persistent inflammatory state that hinders tissue regeneration.

Factors contributing to sárþreyta include the duration of the wound, repetitive trauma or shear forces, persistent inflammation from underlying conditions like venous insufficiency or diabetes, and the accumulation of senescent cells. Identifying and addressing sárþreyta is crucial for effective wound management, as it necessitates a shift in treatment strategy from standard wound care to more targeted approaches. These may include therapies aimed at reducing inflammation, debriding non-viable tissue, modulating MMP activity, or promoting cellular rejuvenation.