sproutyrelated
Sproutyrelated refers to proteins related to the Sprouty family, including Sprouty (SPRY) proteins and Sprouty-related (SPRED) proteins in humans. These factors are negative regulators of receptor tyrosine kinase signaling, especially the Ras/MAPK pathway, and influence cell proliferation, differentiation, and morphogenesis during development and in adulthood.
Sprouty proteins typically contain a Sprouty (SPRY) domain at the C-terminus, necessary for inhibitory activity and
Functionally, Sprouty-related proteins dampen signaling from several receptor tyrosine kinases, including FGFR, EGFR, and VEGFR, by
Genetically, SPRED1 mutations cause Legius syndrome, a Ras/MAPK pathway-related developmental disorder. Alterations in SPRED2 or SPRED3
Sprouty-related proteins were first identified as regulators of FGF signaling in Drosophila and are conserved in