regulonthrough
Regulonthrough is a theoretical construct in systems biology that denotes regulatory influence that is transmitted through one or more intermediary regulators, rather than exerted directly on target genes. The term emphasizes the dependence on regulatory cascades within gene regulatory networks (GRNs).
Overview: In a regulonthrough scenario, a primary regulator modulates the activity or expression of a secondary
Biological significance: Regulated pathways frequently rely on cascaded control to coordinate development, stress responses, and metabolism.
Applications: In research, regulonthrough analysis aids in mapping GRNs, inferring causality, and predicting system responses to
Measurement and challenges: Inferring regulonthrough relationships requires time-series data, perturbation experiments, and integrative modeling. Challenges include
See also: regulon, gene regulatory network, cascade, feed-forward loop.