próresolutivos

Proresolutivos are a class of endogenous lipid mediators derived from polyunsaturated fatty acids (PUFAs), primarily omega-3 and omega-6 fatty acids. Unlike pro-inflammatory mediators, which promote and sustain inflammation, proresolutivos are actively involved in the resolution of inflammation. They represent a crucial component of the body's natural anti-inflammatory and tissue repair mechanisms.

The discovery and characterization of proresolutivos have significantly advanced our understanding of inflammation, revealing that it is not merely a passive process that subsides on its own, but rather a highly regulated, active biological program. These lipid mediators act through specific receptors on various cell types, including immune cells, to orchestrate a complex cascade of events that dampen inflammation, clear inflammatory debris, and promote tissue regeneration.

Key families of proresolutivos include resolvins, protectins, and maresins. Each family is derived from specific PUFAs and possesses distinct chemical structures and biological activities. For example, resolvins are derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), while protectins and maresins are primarily derived from DHA. These molecules work synergistically to bring about the cessation of inflammation and facilitate a return to homeostasis. Research into proresolutivos holds significant therapeutic potential for a wide range of inflammatory conditions, including cardiovascular disease, arthritis, and neurodegenerative disorders.