perinucleaire

Perinucleaire is an adjective used in biology to describe localization around the nucleus. In French, the term is formed from peri- (around) and nucléaire (nuclear). It is commonly applied to describe structures, regions, or staining patterns that are situated near the nucleus of a cell.

In anatomical and cellular terms, the perinuclear region encompasses the area surrounding the nuclear envelope, including the perinuclear space—the gap between the inner and outer nuclear membranes. This space is continuous with the lumen of the endoplasmic reticulum, reflecting the close physical and functional connection between the nucleus and the broader endomembrane system. The perinuclear cytoplasm refers to the portion of the cytoplasm adjacent to the nuclear envelope.

Functionally, the perinuclear region is important for processes involving transport and signaling between the nucleus and the cytoplasm. The rough endoplasmic reticulum, which is often concentrated near the nucleus, participates in protein synthesis and trafficking and interacts with the nucleus through various transport pathways. The organization of the perinuclear area can influence cellular activities such as mitosis, polarity, and the coordination of nuclear-cytoplasmic exchange.

In practice, perinucleaire is used in microscopy and pathology to describe where proteins, organelles, or staining reactions are located relative to the nucleus. Distinct perinuclear localization patterns can aid in the interpretation of cellular architecture, protein function, or disease-associated changes.

Related terms include perinuclear space, nuclear envelope, nucleoplasm, and perinuclear cytoplasm.