peptidepeptoids
Peptidepeptoids are a class of hybrid macromolecules that merge features of peptides and peptoids. They combine conventional amino acid residues linked by peptide bonds with N-substituted glycine units (peptoids) within the same polymer backbone, producing a mixed sequence that can leverage the advantages of both chemistries. The concept aims to retain the recognition properties of peptides while improving stability and design flexibility offered by peptoids.
Structurally, peptidepeptoids feature a backbone that includes both amide bonds and N-substituted linkages. Some residues may
Synthesis and design generally combine methods from peptide and peptoid chemistry. Sequential solid-phase synthesis can be
Properties and applications are driven by the mixed backbone. The peptoid component often confers proteolytic resistance