offtargetvaikutusten
Off-target effects, also known as off-target activities, refer to the unintended consequences or actions that occur when a substance, such as a drug or a gene, interacts with targets other than its intended target. These effects can arise due to various factors, including structural similarities between the intended target and off-targets, or due to the substance's ability to bind to multiple targets. Off-target effects can have significant implications in pharmacology, toxicology, and gene therapy.
In pharmacology, off-target effects can lead to adverse drug reactions, where a drug produces an unwanted effect
In gene therapy, off-target effects can occur when a gene-editing tool, such as CRISPR-Cas9, inadvertently modifies
Understanding and predicting off-target effects is a critical aspect of drug discovery, toxicology, and gene therapy.