nociplastinen
Nociplastic pain is a term used to describe pain that arises from altered nociception without clear evidence of tissue damage, disease of the somatosensory nervous system, or a predominant neuropathic mechanism. The concept was introduced by the International Association for the Study of Pain (IASP) to classify pain that does not fit neatly into nociceptive or neuropathic categories and is thought to reflect changes in central pain processing rather than peripheral injury alone.
Pathophysiology is thought to involve central sensitization and impaired or altered endogenous pain modulation. Amplified signaling
Clinical features commonly include persistent or recurrent pain that is regional or widespread and may be
Diagnosis relies on clinical judgment, history, and the exclusion of other causes. Tools such as questionnaires