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neuroplasticity

Neuroplasticity, or brain plasticity, is the ability of the nervous system to change its structure and function in response to learning, experience, development, injury, or disease. This capacity exists throughout life, though the extent and nature of change vary by age and context. Plastic changes can be structural, involving growth or pruning of dendrites, axons, and synapses, or functional, involving shifts in the activity or mapping of neural circuits. Mechanisms include synaptic plasticity, such as long-term potentiation and long-term depression, synaptogenesis, dendritic remodeling, changes in white-matter connectivity, and the unmasking of latent synapses.

Plasticity can be functional, with brain regions taking over functions after injury or changing representations through

Factors influencing plasticity include age, sleep, nutrition, genetics, hormones, and the intensity, repetition, and timing of

Applications of plasticity research include rehabilitation strategies such as constraint-induced movement therapy, targeted neurostimulation techniques, and

Limitations of the concept include variability across individuals and brain regions, and the challenge of proving

learning,
and
structural,
with
physical
alterations
to
connections.
Experience-dependent
plasticity
refers
to
changes
driven
by
learning
and
environment,
while
developmental
plasticity
is
particularly
pronounced
during
early
life
and
in
childhood.
Metaplasticity
and
homeostatic
plasticity
describe
the
regulation
of
plastic
changes
to
maintain
stability.
activity.
While
plasticity
enables
recovery
after
stroke
or
trauma
and
supports
skill
acquisition,
maladaptive
plasticity
can
also
contribute
to
chronic
pain,
tinnitus,
or
phantom
limbs
if
reorganized
pathways
reinforce
improper
signaling.
motor
or
cognitive
training
programs.
Advances
in
imaging
and
stimulation
methods
(fMRI,
diffusion
tensor
imaging,
TMS,
tDCS)
help
study
plastic
changes
and
guide
interventions.
causality
in
humans.
Nevertheless,
neuroplasticity
remains
a
central
framework
for
understanding
learning,
recovery,
and
the
brain's
capacity
to
adapt.