nephrotoxikus
Nephrotoxikus, or nephrotoxic in English, describes substances or agents that can cause damage to the kidneys. The term is used in pharmacology, toxicology, and clinical medicine to categorize compounds that impair renal function. Nephrotoxicity is a common cause of acute kidney injury (AKI) and can result from drugs, environmental toxins, metabolic byproducts, or endogenous insults.
Mechanisms of nephrotoxicity include direct injury to renal tubular epithelial cells, especially in the proximal tubules;
Common nephrotoxic agents span multiple categories. They include aminoglycoside antibiotics (for example, gentamicin, tobramycin); platinum-based chemotherapeutics
Diagnosis relies on a temporal association between exposure and kidney function decline, with monitoring of serum