miR34c
miR-34c is a microRNA in the miR-34 family, produced from the MIR34C gene. It is part of a cluster that also gives rise to miR-34b and shares regulatory and functional characteristics with its family members. Like other microRNAs, miR-34c functions by guiding the RNA-induced silencing complex to target mRNAs, leading to translational repression or mRNA degradation. The mature miR-34c is generated as two strands, miR-34c-5p and miR-34c-3p, each capable of post-transcriptional regulation.
Regulation and biogenesis of miR-34c are closely linked to cellular stress responses. The miR-34 family is transcriptionally
Functional role and targets of miR-34c are diverse, with a focus on tumor suppression. miR-34c inhibits cell
Clinical relevance is primarily in oncology. miR-34c expression is often reduced in cancers, and restoration of